Title |
Molecular crosstalk between apoptosis and autophagy induced by a novel 2-methoxyestradiol analogue in cervical adenocarcinoma cells
|
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Published in |
Cancer Cell International, August 2013
|
DOI | 10.1186/1475-2867-13-87 |
Pubmed ID | |
Authors |
Anne E Theron, Elsie M Nolte, Laurence Lafanechère, Annie M Joubert |
Abstract |
2-Methoxyestradiol has been shown to induce both autophagy and apoptosis in various carcinogenic cell lines. Although a promising anti-cancer agent, it has poor bioavailability and rapid in vivo metabolism which decreases its efficiency. In order to improve 2-methoxyestradiol's anti-proliferative properties, a novel 2-methoxyestradiol analogue, 2-ethyl-3-O-sulphamoyl-estra-1,3,5 (10)16-tetraene (ESE-16), was previously in silico-designed in our laboratory. This study investigated ESE-16 for its anti-proliferative potential on a cervical adenocarcinoma cell (HeLa) cell line. Additionally, the possible intracellular crosstalk mechanisms between the two types of cell death were investigated. |
X Demographics
Geographical breakdown
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Central African Republic | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Chile | 2 | 7% |
South Africa | 1 | 3% |
Unknown | 26 | 90% |
Demographic breakdown
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Student > Master | 7 | 24% |
Researcher | 6 | 21% |
Student > Ph. D. Student | 5 | 17% |
Student > Bachelor | 4 | 14% |
Student > Postgraduate | 2 | 7% |
Other | 3 | 10% |
Unknown | 2 | 7% |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 2 | 7% |
Unknown | 4 | 14% |