Title |
Detection of lamivudine-resistant variants and mutations related to reduced antigenicity of HBsAg in individuals from the cities of Santos and São Paulo, Brazil
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Published in |
Virology Journal, October 2013
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DOI | 10.1186/1743-422x-10-320 |
Pubmed ID | |
Authors |
Nathalia Mantovani, Maira Cicero, Luiz Claudio Santana, Carla Silveira, Eliane Pereira do Carmo, Paulo Roberto Ferreira Abrão, Ricardo Sobhie Diaz, Marcos Montani Caseiro, Shirley Vasconcelos Komninakis |
Abstract |
Continuous long-term treatment is recommended to reduce the hepatitis B virus (HBV) viral load. However, as a consequence, resistance mutations can emerge and be transmitted to other individuals. The polymerase (POL) gene overlaps the surface (S) gene. Thus, during treatment, mutations in the POL gene may lead to changes in hepatitis B surface antigen (HBsAg). The purpose of this study was to evaluate the frequency of lamivudine and vaccine escape mutations in HBsAg-positive blood donors from the city of Santos and in untreated HBV mono-infected patients from the city of São Paulo, Brazil. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 20% |
Researcher | 3 | 15% |
Student > Ph. D. Student | 3 | 15% |
Student > Bachelor | 1 | 5% |
Professor | 1 | 5% |
Other | 3 | 15% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 40% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Psychology | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Other | 0 | 0% |
Unknown | 7 | 35% |