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Pectin enhances the effect of fecal microbiota transplantation in ulcerative colitis by delaying the loss of diversity of gut flora

Overview of attention for article published in BMC Microbiology, November 2016
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Title
Pectin enhances the effect of fecal microbiota transplantation in ulcerative colitis by delaying the loss of diversity of gut flora
Published in
BMC Microbiology, November 2016
DOI 10.1186/s12866-016-0869-2
Pubmed ID
Authors

Yao Wei, Jianfeng Gong, Weiming Zhu, Hongliang Tian, Chao Ding, Lili Gu, Ning Li, Jieshou Li

Abstract

Fecal microbiota transplantation (FMT) induces remission in ulcerative colitis (UC). However, the treatment effect of FMT diminishes over time. Maintaining the diversity of the gut flora for long periods may improve the effects of FMT in UC. Pectin, which can be fermented by gut microbiota into short-chain fatty acids, is postulated to shape the composition and maintain the balance of gut microbiota following transplantation. This study investigated whether pectin could enhance the effects of FMT in UC patients. Three FMT patients and four FMTP patients achieved the primary outcome. The Mayo scores of the FMTP group were lower than those of the FMT group at weeks 4 and 12 (P = 0.042 and P = 0.042, respectively). There were no differences in the diversity of the gut flora between the two groups at weeks 4 and 12; however, the composition of the gut flora of the FMTP group was more similar than the FMT group to that of the donor at all-time points post-treatment. Pectin decreased the Mayo score by preserving the diversity of the gut flora following FMT for UC. Current Controlled Trial NCT02016469 . Registered 10 November 2013.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 <1%
Unknown 178 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 29 16%
Researcher 27 15%
Student > Bachelor 25 14%
Student > Ph. D. Student 23 13%
Student > Doctoral Student 8 4%
Other 28 16%
Unknown 39 22%
Readers by discipline Count As %
Medicine and Dentistry 43 24%
Agricultural and Biological Sciences 17 9%
Immunology and Microbiology 17 9%
Biochemistry, Genetics and Molecular Biology 13 7%
Pharmacology, Toxicology and Pharmaceutical Science 13 7%
Other 26 15%
Unknown 50 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2022.
All research outputs
#14,705,075
of 24,661,808 outputs
Outputs from BMC Microbiology
#1,353
of 3,393 outputs
Outputs of similar age
#169,863
of 317,292 outputs
Outputs of similar age from BMC Microbiology
#19
of 64 outputs
Altmetric has tracked 24,661,808 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,393 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,292 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.