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Association of a common TLR-6 polymorphism with coronary artery disease – implications for healthy ageing?

Overview of attention for article published in Immunity & Ageing, October 2013
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Title
Association of a common TLR-6 polymorphism with coronary artery disease – implications for healthy ageing?
Published in
Immunity & Ageing, October 2013
DOI 10.1186/1742-4933-10-43
Pubmed ID
Authors

Lutz Hamann, Alexander Koch, Saubashya Sur, Nadja Hoefer, Christiane Glaeser, Susanne Schulz, Michael Gross, Andre Franke, Ute Nöthlings, Kai Zacharowski, Ralf R Schumann

Abstract

The pro-inflammatory status of the elderly triggers most of the age-related diseases such as cancer and atherosclerosis. Atherosclerosis, the leading cause world wide of morbidity and death, is an inflammatory disease influenced by life-style and genetic host factors. Stimuli such as oxLDL or microbial ligands have been proposed to trigger inflammation leading to atherosclerosis. It has recently been shown that oxLDL activates immune cells via the Toll-like receptor (TLR) 4/6 complex. Several common single nucleotide polymorphisms (SNPs) of the TLR system have been associated with atherosclerosis. To investigate the role of TLR-6 we analyzed the association of the TLR-6 SNP Pro249Ser with atherogenesis.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Germany 1 4%
Unknown 22 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 25%
Professor 2 8%
Researcher 2 8%
Professor > Associate Professor 2 8%
Student > Master 2 8%
Other 4 17%
Unknown 6 25%
Readers by discipline Count As %
Medicine and Dentistry 7 29%
Agricultural and Biological Sciences 5 21%
Biochemistry, Genetics and Molecular Biology 4 17%
Nursing and Health Professions 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 6 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2013.
All research outputs
#18,353,475
of 22,729,647 outputs
Outputs from Immunity & Ageing
#295
of 370 outputs
Outputs of similar age
#158,107
of 212,653 outputs
Outputs of similar age from Immunity & Ageing
#1
of 1 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 370 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,653 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them