Title |
Association of a common TLR-6 polymorphism with coronary artery disease – implications for healthy ageing?
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Published in |
Immunity & Ageing, October 2013
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DOI | 10.1186/1742-4933-10-43 |
Pubmed ID | |
Authors |
Lutz Hamann, Alexander Koch, Saubashya Sur, Nadja Hoefer, Christiane Glaeser, Susanne Schulz, Michael Gross, Andre Franke, Ute Nöthlings, Kai Zacharowski, Ralf R Schumann |
Abstract |
The pro-inflammatory status of the elderly triggers most of the age-related diseases such as cancer and atherosclerosis. Atherosclerosis, the leading cause world wide of morbidity and death, is an inflammatory disease influenced by life-style and genetic host factors. Stimuli such as oxLDL or microbial ligands have been proposed to trigger inflammation leading to atherosclerosis. It has recently been shown that oxLDL activates immune cells via the Toll-like receptor (TLR) 4/6 complex. Several common single nucleotide polymorphisms (SNPs) of the TLR system have been associated with atherosclerosis. To investigate the role of TLR-6 we analyzed the association of the TLR-6 SNP Pro249Ser with atherogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 4% |
Germany | 1 | 4% |
Unknown | 22 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 25% |
Professor | 2 | 8% |
Researcher | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Student > Master | 2 | 8% |
Other | 4 | 17% |
Unknown | 6 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 29% |
Agricultural and Biological Sciences | 5 | 21% |
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Nursing and Health Professions | 1 | 4% |
Neuroscience | 1 | 4% |
Other | 0 | 0% |
Unknown | 6 | 25% |