Title |
Unique microbial communities persist in individual cystic fibrosis patients throughout a clinical exacerbation
|
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Published in |
Microbiome, November 2013
|
DOI | 10.1186/2049-2618-1-27 |
Pubmed ID | |
Authors |
Katherine E Price, Thomas H Hampton, Alex H Gifford, Emily L Dolben, Deborah A Hogan, Hilary G Morrison, Mitchell L Sogin, George A O’Toole |
Abstract |
Cystic fibrosis (CF) is caused by inherited mutations in the cystic fibrosis transmembrane conductance regulator gene and results in a lung environment that is highly conducive to polymicrobial infection. Over a lifetime, decreasing bacterial diversity and the presence of Pseudomonas aeruginosa in the lung are correlated with worsening lung disease. However, to date, no change in community diversity, overall microbial load or individual microbes has been shown to correlate with the onset of an acute exacerbation in CF patients. We followed 17 adult CF patients throughout the course of clinical exacerbation, treatment and recovery, using deep sequencing and quantitative PCR to characterize spontaneously expectorated sputum samples |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 24% |
United Kingdom | 3 | 18% |
Italy | 1 | 6% |
Mexico | 1 | 6% |
Cameroon | 1 | 6% |
France | 1 | 6% |
Unknown | 6 | 35% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 59% |
Scientists | 7 | 41% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
Canada | 1 | <1% |
Unknown | 137 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 24% |
Researcher | 27 | 19% |
Student > Master | 13 | 9% |
Student > Bachelor | 9 | 6% |
Student > Doctoral Student | 8 | 6% |
Other | 24 | 17% |
Unknown | 27 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 36 | 25% |
Immunology and Microbiology | 20 | 14% |
Biochemistry, Genetics and Molecular Biology | 19 | 13% |
Medicine and Dentistry | 15 | 11% |
Environmental Science | 6 | 4% |
Other | 14 | 10% |
Unknown | 32 | 23% |