Title |
Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy
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Published in |
Respiratory Research, November 2013
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DOI | 10.1186/1465-9921-14-117 |
Pubmed ID | |
Authors |
Koen JP Verhees, Nicholas AM Pansters, Hoeke A Baarsma, Alexander HV Remels, Astrid Haegens, Chiel C de Theije, Annemie MWJ Schols, Reinoud Gosens, Ramon CJ Langen |
Abstract |
Chronic obstructive pulmonary disease (COPD) is accompanied by pulmonary inflammation and associated with extra-pulmonary manifestations, including skeletal muscle atrophy. Glycogen synthase kinase-3 (GSK-3) has been implicated in the regulation of muscle protein- and myonuclear turnover; two crucial processes that determine muscle mass. In the present study we investigated the effect of the selective GSK-3 inhibitor SB216763 on muscle mass in a guinea pig model of lipopolysaccharide (LPS)-induced pulmonary inflammation-associated muscle atrophy. |
X Demographics
Geographical breakdown
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Netherlands | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 25% |
Researcher | 7 | 19% |
Student > Master | 4 | 11% |
Student > Bachelor | 3 | 8% |
Professor | 1 | 3% |
Other | 2 | 6% |
Unknown | 10 | 28% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 19% |
Agricultural and Biological Sciences | 6 | 17% |
Medicine and Dentistry | 5 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Nursing and Health Professions | 2 | 6% |
Other | 4 | 11% |
Unknown | 10 | 28% |