Title |
Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection
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Published in |
Retrovirology, November 2013
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DOI | 10.1186/1742-4690-10-127 |
Pubmed ID | |
Authors |
Elisabeth Littwitz, Sandra Francois, Ulf Dittmer, Kathrin Gibbert |
Abstract |
In many virus infections natural killer (NK) cells are critical for the rapid containment of virus replication. Polymorphisms in NK cell receptors as well as viral escape from NK cell responses are associated with pathogenesis and viral loads in HIV-infected individuals, emphasizing their importance in retroviral immunity. In contrast, NK cells of LCMV-infected mice dampened virus-specific T cell responses resulting in impaired virus control. Thus, the exact role of NK cells during different phases of viral infections remains elusive. In this study we characterized the NK cell response at different time points of an acute retroviral infection by using the Friend retrovirus (FV) mouse model. |
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Mendeley readers
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