Title |
Identification and characterization of the merozoite surface protein 1 (msp1) gene in a host-generalist avian malaria parasite, Plasmodium relictum (lineages SGS1 and GRW4) with the use of blood transcriptome
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Published in |
Malaria Journal, October 2013
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DOI | 10.1186/1475-2875-12-381 |
Pubmed ID | |
Authors |
Olof Hellgren, Megan Kutzer, Staffan Bensch, Gediminas Valkiūnas, Vaidas Palinauskas |
Abstract |
The merozoite surface protein 1 (msp1) is one of the most studied vaccine candidate genes in mammalian Plasmodium spp. to have been used for investigations of epidemiology, population structures, and immunity to infections. However methodological difficulties have impeded the use of nuclear markers such as msp1 in Plasmodium parasites causing avian malaria. Data from an infection transcriptome of the host generalist avian malaria parasite Plasmodium relictum was used to identify and characterize the msp1 gene from two different isolates (mtDNA lineages SGS1 and GRW4). The aim was to investigate whether the msp1 gene in avian malaria species shares the properties of the msp1 gene in Plasmodium falciparum in terms of block variability, conserved anchor points and repeat motifs, and further to investigate the degree to which the gene might be informative in avian malaria parasites for population and epidemiological studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 4% |
Portugal | 1 | 1% |
Lithuania | 1 | 1% |
Brazil | 1 | 1% |
United Kingdom | 1 | 1% |
India | 1 | 1% |
Unknown | 74 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 22% |
Student > Master | 13 | 16% |
Student > Bachelor | 10 | 12% |
Researcher | 9 | 11% |
Student > Postgraduate | 7 | 9% |
Other | 14 | 17% |
Unknown | 11 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 48% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Medicine and Dentistry | 7 | 9% |
Immunology and Microbiology | 5 | 6% |
Environmental Science | 4 | 5% |
Other | 6 | 7% |
Unknown | 14 | 17% |