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The end of a dogma: the safety of doxycycline use in young children for malaria treatment

Overview of attention for article published in Malaria Journal, April 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

twitter
12 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
40 Dimensions

Readers on

mendeley
136 Mendeley
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Title
The end of a dogma: the safety of doxycycline use in young children for malaria treatment
Published in
Malaria Journal, April 2017
DOI 10.1186/s12936-017-1797-9
Pubmed ID
Authors

Tiphaine Gaillard, Sébastien Briolant, Marylin Madamet, Bruno Pradines

Abstract

Anti-malarial drug resistance to chloroquine and sulfadoxine-pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance to artemisinin-based combination therapy (ACT) in Southeast Asia highlights the need to identify new anti-malarial drugs. Doxycycline is recommended for malaria chemoprophylaxis for travel in endemic areas, or in combination with the use of quinine for malaria treatment when ACT is unavailable or when the treatment of severe malaria with artesunate fails. However, doxycycline is not used in young children under 8 years of age due to its contraindication due to the risk of yellow tooth discolouration and dental enamel hypoplasia. Doxycycline was developed after tetracycline and was labelled with the same side-effects as the earlier tetracyclines. However, recent studies report little or no effects of doxycycline on tooth staining or dental enamel hypoplasia in children under 8 years of age. In the United States, the Centers for Disease Control and Prevention have recommended the use of doxycycline for the treatment of acute and chronic Q fever and tick-borne rickettsial diseases in young children. It is time to rehabilitate doxycycline and to recommend it for malaria treatment in children under 8 years of age.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mozambique 1 <1%
Brazil 1 <1%
Unknown 134 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 15%
Student > Master 17 13%
Other 15 11%
Student > Bachelor 14 10%
Student > Ph. D. Student 12 9%
Other 27 20%
Unknown 31 23%
Readers by discipline Count As %
Medicine and Dentistry 51 38%
Pharmacology, Toxicology and Pharmaceutical Science 13 10%
Biochemistry, Genetics and Molecular Biology 7 5%
Immunology and Microbiology 6 4%
Agricultural and Biological Sciences 6 4%
Other 14 10%
Unknown 39 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2022.
All research outputs
#2,628,186
of 22,547,209 outputs
Outputs from Malaria Journal
#595
of 5,504 outputs
Outputs of similar age
#48,226
of 286,880 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 22,547,209 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,504 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,880 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them