Title |
Iodine and doxorubicin, a good combination for mammary cancer treatment: antineoplastic adjuvancy, chemoresistance inhibition, and cardioprotection
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Published in |
Molecular Cancer, May 2013
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DOI | 10.1186/1476-4598-12-45 |
Pubmed ID | |
Authors |
Yunuen Alfaro, Guadalupe Delgado, Alfonso Cárabez, Brenda Anguiano, Carmen Aceves |
Abstract |
Although mammary cancer (MC) is the most common malignant neoplasia in women, the mortality for this cancer has decreased principally because of early detection and the use of neoadjuvant chemotherapy. Of several preparations that cause MC regression, doxorubicin (DOX) is the most active, first-line monotherapeutic. Nevertheless, its use is limited due to the rapid development of chemoresistance and to the cardiotoxicity caused by free radicals. In previous studies we have shown that supplementation with molecular iodine (I2) has a powerful antineoplastic effect in methylnitrosourea (MNU)-induced experimental models of MC. These studies also showed a consistent antioxidant effect of I2 in normal and tumoral tissues. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 2% |
Unknown | 64 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 17% |
Student > Master | 11 | 17% |
Student > Bachelor | 8 | 12% |
Researcher | 5 | 8% |
Student > Postgraduate | 5 | 8% |
Other | 17 | 26% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 26% |
Biochemistry, Genetics and Molecular Biology | 9 | 14% |
Agricultural and Biological Sciences | 9 | 14% |
Veterinary Science and Veterinary Medicine | 5 | 8% |
Nursing and Health Professions | 4 | 6% |
Other | 11 | 17% |
Unknown | 10 | 15% |