Title |
Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption
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Published in |
Arthritis Research & Therapy, November 2013
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DOI | 10.1186/ar4366 |
Pubmed ID | |
Authors |
Humaira Rasheed, Amanda Phipps-Green, Ruth Topless, Jade E Hollis-Moffatt, Jennie Harré Hindmarsh, Christopher Franklin, Nicola Dalbeth, Peter B Jones, Douglas HN White, Lisa K Stamp, Tony R Merriman |
Abstract |
The T allele of a single nucleotide polymorphism (SNP: rs2544390) in lipoprotein receptor-related protein 2 (LRP2) is associated with higher serum urate and risk of gout in Japanese individuals. SNP rs2544390 also interacts with alcohol consumption in determining hyperuricemia in this population. We investigated the association of rs2544390 with gout, and interaction with all types of alcohol consumption in European and New Zealand (NZ) Māori and Pacific subjects, and a Māori study cohort from the East Coast region of NZ's North Island. |
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