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Is serum HMGB1 a biomarker in ANCA-associated vasculitis?

Overview of attention for article published in Arthritis Research & Therapy, September 2013
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Title
Is serum HMGB1 a biomarker in ANCA-associated vasculitis?
Published in
Arthritis Research & Therapy, September 2013
DOI 10.1186/ar4284
Pubmed ID
Authors

Alexandre Wagner Silva de Souza, Johanna Westra, Johan Bijzet, Pieter C Limburg, Coen A Stegeman, Marc Bijl, Cees GM Kallenberg

Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are systemic inflammatory disorders that include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), Churg-Strauss syndrome and renal limited vasculitis (RLV). Extracellular high-mobility group box 1 (HMGB1) acts as an alarmin and has been shown to be a biomarker of disease activity as well as an autoantigen in systemic lupus erythematosus (SLE) and, possibly, in AAV. This study aims to assess antibodies against HMGB1 and HMGB1 levels as biomarkers for AAV disease activity and predictors of relapsing disease.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
China 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 35%
Student > Ph. D. Student 6 19%
Librarian 2 6%
Student > Master 2 6%
Unspecified 2 6%
Other 4 13%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 14 45%
Agricultural and Biological Sciences 3 10%
Biochemistry, Genetics and Molecular Biology 2 6%
Unspecified 2 6%
Immunology and Microbiology 1 3%
Other 3 10%
Unknown 6 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2014.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#2,906
of 3,381 outputs
Outputs of similar age
#157,844
of 209,012 outputs
Outputs of similar age from Arthritis Research & Therapy
#50
of 55 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,012 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.