Title |
Is serum HMGB1 a biomarker in ANCA-associated vasculitis?
|
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Published in |
Arthritis Research & Therapy, September 2013
|
DOI | 10.1186/ar4284 |
Pubmed ID | |
Authors |
Alexandre Wagner Silva de Souza, Johanna Westra, Johan Bijzet, Pieter C Limburg, Coen A Stegeman, Marc Bijl, Cees GM Kallenberg |
Abstract |
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are systemic inflammatory disorders that include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), Churg-Strauss syndrome and renal limited vasculitis (RLV). Extracellular high-mobility group box 1 (HMGB1) acts as an alarmin and has been shown to be a biomarker of disease activity as well as an autoantigen in systemic lupus erythematosus (SLE) and, possibly, in AAV. This study aims to assess antibodies against HMGB1 and HMGB1 levels as biomarkers for AAV disease activity and predictors of relapsing disease. |
X Demographics
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Netherlands | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 3% |
China | 1 | 3% |
Unknown | 29 | 94% |
Demographic breakdown
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Researcher | 11 | 35% |
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Librarian | 2 | 6% |
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