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Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells

Overview of attention for article published in Journal of Translational Medicine, November 2013
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2 X users

Citations

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143 Dimensions

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193 Mendeley
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Title
Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells
Published in
Journal of Translational Medicine, November 2013
DOI 10.1186/1479-5876-11-280
Pubmed ID
Authors

Birdal Bilir, Omer Kucuk, Carlos S Moreno

Abstract

Triple-negative breast cancer (TNBC) is an aggressive clinical subtype of breast cancer that is characterized by the lack of estrogen receptor (ER) and progesterone receptor (PR) expression as well as human epidermal growth factor receptor 2 (HER2) overexpression. The TNBC subtype constitutes approximately 10%-20% of all breast cancers, but has no effective molecular targeted therapies. Previous meta-analysis of gene expression profiles of 587 TNBC cases from 21 studies demonstrated high expression of Wnt signaling pathway-associated genes in basal-like 2 and mesenchymal subtypes of TNBC. In this study, we investigated the potential of Wnt pathway inhibitors in effective treatment of TNBC.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Netherlands 1 <1%
India 1 <1%
Turkey 1 <1%
Unknown 187 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 45 23%
Researcher 27 14%
Student > Master 23 12%
Student > Bachelor 22 11%
Student > Doctoral Student 17 9%
Other 19 10%
Unknown 40 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 52 27%
Biochemistry, Genetics and Molecular Biology 46 24%
Medicine and Dentistry 28 15%
Engineering 5 3%
Pharmacology, Toxicology and Pharmaceutical Science 4 2%
Other 14 7%
Unknown 44 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2013.
All research outputs
#18,353,475
of 22,729,647 outputs
Outputs from Journal of Translational Medicine
#2,943
of 3,974 outputs
Outputs of similar age
#159,733
of 214,638 outputs
Outputs of similar age from Journal of Translational Medicine
#38
of 68 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,974 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,638 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.