Title |
Encephalitozoon intestinalis infection increases host cell mutation frequency
|
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Published in |
Infectious Agents and Cancer, November 2013
|
DOI | 10.1186/1750-9378-8-43 |
Pubmed ID | |
Authors |
Cory Ann Leonard, Maria Schell, Robert Vincent Schoborg, James Russell Hayman |
Abstract |
Microsporidia are obligate intracellular opportunistic fungi that cause significant pathology in immunocompromised hosts. However, 11 percent of immunocompetent individuals in the general population are microsporidia-seropositive, indicating that severe immune suppression may not be a prerequisite for infection. Encephalitozoon intestinalis is transmitted in contaminated water and initially infects gastro-intestinal enterocytes, leading to diarrheal disease. This organism can also disseminate to many other organs. A recent report suggests that microsporidia can establish persistent infections, which anti-fungal treatment does not eradicate. Like other intracellular pathogens, microsporidia infection stresses the host cell and infected individuals have elevated hydrogen peroxide and free radical levels. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 50% |
Canada | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Scientists | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
France | 1 | 3% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 18% |
Researcher | 4 | 12% |
Lecturer | 3 | 9% |
Other | 3 | 9% |
Professor > Associate Professor | 3 | 9% |
Other | 9 | 26% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 35% |
Immunology and Microbiology | 5 | 15% |
Medicine and Dentistry | 3 | 9% |
Veterinary Science and Veterinary Medicine | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Other | 3 | 9% |
Unknown | 6 | 18% |