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Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuation

Overview of attention for article published in BMC Genomics, November 2013
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  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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Title
Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuation
Published in
BMC Genomics, November 2013
DOI 10.1186/1471-2164-14-763
Pubmed ID
Authors

Monica J Pedroni, Kerry S Sondgeroth, Gina M Gallego-Lopez, Ignacio Echaide, Audrey OT Lau

Abstract

Loss of virulence is a phenotypic adaptation commonly seen in prokaryotic and eukaryotic pathogens. This mechanism is not well studied, especially in organisms with multiple host and life cycle stages such as Babesia, a tick-transmitted hemoparasite of humans and animals. B. bovis, which infects cattle, has naturally occurring virulent strains that can be reliably attenuated in vivo. Previous studies suggest the virulence loss mechanism may involve post-genomic modification. We investigated the transcriptome profiles of two geographically distinct B. bovis virulent and attenuated strain pairs to better understand virulence loss and to gain insight into pathogen adaptation strategies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 29%
Researcher 6 15%
Student > Doctoral Student 5 12%
Student > Master 4 10%
Student > Bachelor 2 5%
Other 2 5%
Unknown 10 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 44%
Veterinary Science and Veterinary Medicine 4 10%
Biochemistry, Genetics and Molecular Biology 3 7%
Immunology and Microbiology 2 5%
Nursing and Health Professions 1 2%
Other 2 5%
Unknown 11 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2014.
All research outputs
#13,901,154
of 22,729,647 outputs
Outputs from BMC Genomics
#5,329
of 10,628 outputs
Outputs of similar age
#118,014
of 215,641 outputs
Outputs of similar age from BMC Genomics
#56
of 162 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,628 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,641 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 162 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.