Title |
Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuation
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Published in |
BMC Genomics, November 2013
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DOI | 10.1186/1471-2164-14-763 |
Pubmed ID | |
Authors |
Monica J Pedroni, Kerry S Sondgeroth, Gina M Gallego-Lopez, Ignacio Echaide, Audrey OT Lau |
Abstract |
Loss of virulence is a phenotypic adaptation commonly seen in prokaryotic and eukaryotic pathogens. This mechanism is not well studied, especially in organisms with multiple host and life cycle stages such as Babesia, a tick-transmitted hemoparasite of humans and animals. B. bovis, which infects cattle, has naturally occurring virulent strains that can be reliably attenuated in vivo. Previous studies suggest the virulence loss mechanism may involve post-genomic modification. We investigated the transcriptome profiles of two geographically distinct B. bovis virulent and attenuated strain pairs to better understand virulence loss and to gain insight into pathogen adaptation strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Bahrain | 1 | 33% |
France | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 29% |
Researcher | 6 | 15% |
Student > Doctoral Student | 5 | 12% |
Student > Master | 4 | 10% |
Student > Bachelor | 2 | 5% |
Other | 2 | 5% |
Unknown | 10 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 44% |
Veterinary Science and Veterinary Medicine | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Immunology and Microbiology | 2 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 5% |
Unknown | 11 | 27% |