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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Efficient BST2 antagonism by Vpu is critical for early HIV-1 dissemination in humanized mice
|
|---|---|
| Published in |
Retrovirology, November 2013
|
| DOI | 10.1186/1742-4690-10-128 |
| Pubmed ID | |
| Authors |
Vibhuti P Dave, Fadi Hajjar, Mame Massar Dieng, Élie Haddad, Éric A Cohen |
| Abstract |
Vpu is a multifunctional accessory protein that enhances the release of HIV-1 by counteracting the entrapment of nascent virions on infected cell surface mediated by BST2/Tetherin. Vpu-mediated BST2 antagonism involves physical association with BST2 and subsequent mislocalization of the restriction factor to intracellular compartments followed by SCF(β-TrCP) E3 ligase-dependent lysosomal degradation. Apart from BST2 antagonism, Vpu also induces down regulation of several immune molecules, including CD4 and SLAMF6/NTB-A, to evade host immune responses and promote viral dissemination. However, it should be noted that the multiple functions of Vpu have been studied in cell-based assays, and thus it remains unclear how Vpu influences the dynamic of HIV-1 infection in in vivo conditions. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| United States | 1 | 3% |
| Unknown | 27 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 28% |
| Student > Master | 4 | 14% |
| Researcher | 3 | 10% |
| Professor > Associate Professor | 3 | 10% |
| Student > Doctoral Student | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 7 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 41% |
| Immunology and Microbiology | 4 | 14% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Physics and Astronomy | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 8 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2013.
All research outputs
#17,702,587
of 22,729,647 outputs
Outputs from Retrovirology
#914
of 1,105 outputs
Outputs of similar age
#153,808
of 215,641 outputs
Outputs of similar age from Retrovirology
#33
of 55 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,105 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,641 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.