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Mendeley readers
| Title |
Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain
|
|---|---|
| Published in |
Cell Communication and Signaling, November 2013
|
| DOI | 10.1186/1478-811x-11-83 |
| Pubmed ID | |
| Authors |
Anne Mohr, Dirk Fahrenkamp, Natalie Rinis, Gerhard Müller-Newen |
| Abstract |
STAT3 is a transcription factor of central importance in chronic inflammation and cancer. In response to cytokine stimulation STAT3 is phosphorylated on a single tyrosine residue at position 705, dimerizes and accumulates in the nucleus to induce target gene expression. The substitution of tyrosine 705 to phenylalanine leads to a dominant-negative STAT3 mutant (STAT3-YF) which influences the activation of WT-STAT3 in stimulated cells through a mechanism that is not completely understood. In this study we analyzed the molecular mechanism of STAT3-YF dominant-negative activity in IL-6-induced STAT3 signaling and the relevance of the N-terminal domain. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 2% |
| Unknown | 45 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 22% |
| Student > Ph. D. Student | 8 | 17% |
| Researcher | 6 | 13% |
| Student > Doctoral Student | 5 | 11% |
| Student > Master | 4 | 9% |
| Other | 6 | 13% |
| Unknown | 7 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 35% |
| Agricultural and Biological Sciences | 7 | 15% |
| Medicine and Dentistry | 7 | 15% |
| Immunology and Microbiology | 3 | 7% |
| Neuroscience | 2 | 4% |
| Other | 3 | 7% |
| Unknown | 8 | 17% |