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Mendeley readers
Attention Score in Context
| Title |
Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status
|
|---|---|
| Published in |
Stem Cell Research & Therapy, July 2013
|
| DOI | 10.1186/scrt246 |
| Pubmed ID | |
| Authors |
Jason P Awe, Patrick C Lee, Cyril Ramathal, Agustin Vega-Crespo, Jens Durruthy-Durruthy, Aaron Cooper, Saravanan Karumbayaram, William E Lowry, Amander T Clark, Jerome A Zack, Vittorio Sebastiano, Donald B Kohn, April D Pyle, Martin G Martin, Gerald S Lipshutz, Patricia E Phelps, Renee A Reijo Pera, James A Byrne |
| Abstract |
The reprogramming of a patient's somatic cells back into induced pluripotent stem cells (iPSCs) holds significant promise for future autologous cellular therapeutics. The continued presence of potentially oncogenic transgenic elements following reprogramming, however, represents a safety concern that should be addressed prior to clinical applications. The polycistronic stem cell cassette (STEMCCA), an excisable lentiviral reprogramming vector, provides, in our hands, the most consistent reprogramming approach that addresses this safety concern. Nevertheless, most viral integrations occur in genes, and exactly how the integration, epigenetic reprogramming, and excision of the STEMCCA reprogramming vector influences those genes and whether these cells still have clinical potential are not yet known. |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Unknown | 91 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 20% |
| Student > Ph. D. Student | 16 | 17% |
| Student > Bachelor | 14 | 15% |
| Student > Master | 9 | 10% |
| Student > Doctoral Student | 6 | 6% |
| Other | 13 | 14% |
| Unknown | 16 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 32% |
| Biochemistry, Genetics and Molecular Biology | 19 | 20% |
| Medicine and Dentistry | 10 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Chemical Engineering | 2 | 2% |
| Other | 9 | 10% |
| Unknown | 19 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2016.
All research outputs
#3,530,947
of 22,729,647 outputs
Outputs from Stem Cell Research & Therapy
#304
of 2,412 outputs
Outputs of similar age
#30,773
of 197,922 outputs
Outputs of similar age from Stem Cell Research & Therapy
#2
of 22 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,412 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,922 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.