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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of cytochrome P450 in drug interactions
|
|---|---|
| Published in |
Nutrition & Metabolism, October 2008
|
| DOI | 10.1186/1743-7075-5-27 |
| Pubmed ID | |
| Authors |
Zakia Bibi |
| Abstract |
Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepatic cytochrome P450 (P450 or CYP) enzymes being affected by previous administration of other drugs. After coadministration, some drugs act as potent enzyme inducers, whereas others are inhibitors. However, reports of enzyme inhibition are very much more common. Understanding these mechanisms of enzyme inhibition or induction is extremely important in order to give appropriate multiple-drug therapies. In future, it may help to identify individuals at greatest risk of drug interactions and adverse events. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 1 | 10% |
| United States | 1 | 10% |
| United Kingdom | 1 | 10% |
| Canada | 1 | 10% |
| Unknown | 6 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 60% |
| Scientists | 3 | 30% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 420 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| South Africa | 2 | <1% |
| Malaysia | 1 | <1% |
| France | 1 | <1% |
| Portugal | 1 | <1% |
| Israel | 1 | <1% |
| Slovakia | 1 | <1% |
| Brazil | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 406 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 92 | 22% |
| Student > Ph. D. Student | 59 | 14% |
| Student > Master | 59 | 14% |
| Student > Postgraduate | 27 | 6% |
| Researcher | 25 | 6% |
| Other | 53 | 13% |
| Unknown | 105 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 85 | 20% |
| Agricultural and Biological Sciences | 64 | 15% |
| Biochemistry, Genetics and Molecular Biology | 48 | 11% |
| Chemistry | 41 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 32 | 8% |
| Other | 39 | 9% |
| Unknown | 111 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2022.
All research outputs
#3,407,307
of 24,378,020 outputs
Outputs from Nutrition & Metabolism
#311
of 980 outputs
Outputs of similar age
#10,806
of 94,326 outputs
Outputs of similar age from Nutrition & Metabolism
#4
of 5 outputs
Altmetric has tracked 24,378,020 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 980 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.1. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,326 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.