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Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis

Overview of attention for article published in Molecular Cancer, October 2013
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Title
Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis
Published in
Molecular Cancer, October 2013
DOI 10.1186/1476-4598-12-132
Pubmed ID
Authors

Mejdi Moumen, Aurélie Chiche, Charles Decraene, Valérie Petit, Alberto Gandarillas, Marie-Ange Deugnier, Marina A Glukhova, Marisa M Faraldo

Abstract

Basal-like breast cancer is a heterogeneous disease characterized by the expression of basal cell markers, no estrogen or progesterone receptor expression and a lack of HER2 overexpression. Recent studies have linked activation of the Wnt/β-catenin pathway, and its downstream target, Myc, to basal-like breast cancer. Transgenic mice K5ΔNβcat previously generated by our team present a constitutive activation of Wnt/β-catenin signaling in the basal myoepithelial cell layer, resulting in focal mammary hyperplasias that progress to invasive carcinomas. Mammary lesions developed by K5ΔNβcat mice consist essentially of basal epithelial cells that, in contrast to mammary myoepithelium, do not express smooth muscle markers.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 30%
Student > Ph. D. Student 7 16%
Student > Postgraduate 3 7%
Student > Doctoral Student 2 5%
Professor 2 5%
Other 5 11%
Unknown 12 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 32%
Biochemistry, Genetics and Molecular Biology 13 30%
Medicine and Dentistry 3 7%
Immunology and Microbiology 1 2%
Unspecified 1 2%
Other 0 0%
Unknown 12 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2013.
All research outputs
#15,284,663
of 22,729,647 outputs
Outputs from Molecular Cancer
#1,040
of 1,716 outputs
Outputs of similar age
#130,708
of 212,649 outputs
Outputs of similar age from Molecular Cancer
#20
of 27 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,716 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,649 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.