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Calmodulin levels in blood cells as a potential biomarker of Alzheimer’s disease

Overview of attention for article published in Alzheimer's Research & Therapy, November 2013
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Title
Calmodulin levels in blood cells as a potential biomarker of Alzheimer’s disease
Published in
Alzheimer's Research & Therapy, November 2013
DOI 10.1186/alzrt219
Pubmed ID
Authors

Noemí Esteras, Carolina Alquézar, Ana de la Encarnación, Alberto Villarejo, Félix Bermejo-Pareja, Ángeles Martín-Requero

Abstract

The clinical features of Alzheimer's disease (AD) overlap with a number of other dementias and conclusive diagnosis is only achieved at autopsy. Accurate in-life diagnosis requires finding biomarkers suitable for early diagnosis, as well as for discrimination from other types of dementia. Mounting evidence suggests that AD-dependent processes may also affect peripheral cells. We previously reported that calmodulin (CaM) signaling is impaired in AD lymphoblasts. Here, we address the issue as to whether the assessment of CaM levels in peripheral cells could serve as a diagnostic biomarker.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Australia 1 1%
Unknown 65 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 19%
Student > Postgraduate 7 10%
Professor 7 10%
Researcher 6 9%
Student > Master 6 9%
Other 12 18%
Unknown 16 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 19%
Agricultural and Biological Sciences 11 16%
Medicine and Dentistry 8 12%
Chemistry 4 6%
Neuroscience 4 6%
Other 8 12%
Unknown 19 28%