Title |
Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences
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Published in |
BMC Genomics, November 2013
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DOI | 10.1186/1471-2164-14-779 |
Pubmed ID | |
Authors |
Goran Bozinovic, Tim L Sit, Richard Di Giulio, Lauren F Wills, Marjorie F Oleksiak |
Abstract |
Adaptations to a new environment, such as a polluted one, often involve large modifications of the existing phenotypes. Changes in gene expression and regulation during critical developmental stages may explain these phenotypic changes. Embryos from a population of the teleost fish, Fundulus heteroclitus, inhabiting a clean estuary do not survive when exposed to sediment extract from a site highly contaminated with polycyclic aromatic hydrocarbons (PAHs) while embryos derived from a population inhabiting a PAH polluted estuary are remarkably resistant to the polluted sediment extract. We exposed embryos from these two populations to surrogate model PAHs and analyzed changes in gene expression, morphology, and cardiac physiology in order to better understand sensitivity and adaptive resistance mechanisms mediating PAH exposure during development. |
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