Title |
Temporal evaluation of commitment to sexual development in Plasmodium falciparum
|
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Published in |
Malaria Journal, April 2013
|
DOI | 10.1186/1475-2875-12-134 |
Pubmed ID | |
Authors |
Christopher L Peatey, Matthew WA Dixon, Donald L Gardiner, Katharine R Trenholme |
Abstract |
The production of gametocytes is essential for transmission of malaria parasites from the mammalian host to the mosquito vector. However the process by which the asexual blood-stage parasite undergoes commitment to sexual development is not well understood. This process is known to be sensitive to environmental stimuli and it has been suggested that a G protein dependent system may mediate the switch, but there is little evidence that the Plasmodium falciparum genome encodes heterotrimeric G proteins. Previous studies have indicated that the malaria parasite can interact with endogenous erythrocyte G proteins, and other components of the cyclic nucleotide pathway have been identified in P. falciparum. Also, the polypeptide cholera toxin, which induces commitment to gametocytogenesis is known to catalyze the ADP-ribosylation of the α(s) class of heterotrimeric G protein α subunits in mammalian systems has been reported to detect a number of G(α) subunits in P. falciparum-infected red cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Ghana | 1 | 3% |
Switzerland | 1 | 3% |
Unknown | 38 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 33% |
Student > Master | 7 | 18% |
Researcher | 7 | 18% |
Other | 2 | 5% |
Student > Bachelor | 2 | 5% |
Other | 5 | 13% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 19 | 48% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Immunology and Microbiology | 4 | 10% |
Chemistry | 3 | 8% |
Environmental Science | 1 | 3% |
Other | 4 | 10% |
Unknown | 4 | 10% |