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Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways

Overview of attention for article published in Journal of Neuroinflammation, November 2013
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Title
Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways
Published in
Journal of Neuroinflammation, November 2013
DOI 10.1186/1742-2094-10-136
Pubmed ID
Authors

Mohitkumar R Gangwani, Richard J Noel, Ankit Shah, Vanessa Rivera-Amill, Anil Kumar

Abstract

Neurocognitive impairments remain prevalent in HIV-1 infected individuals despite current antiretroviral therapies. It is increasingly becoming evident that astrocytes play a critical role in HIV-1 neuropathogenesis through the production of proinflammatory cytokines/chemokines. HIV-1 viral protein R (Vpr) plays an important role in neuronal dysfunction; however, its role in neuroinflammation is not well characterized. The major objective of this study was to determine the effect of Vpr in induction of proinflammatory chemokine CCL5 in astrocytes and to define the underlying mechanism(s).

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 24%
Student > Ph. D. Student 4 16%
Student > Master 4 16%
Researcher 3 12%
Student > Postgraduate 3 12%
Other 5 20%
Readers by discipline Count As %
Immunology and Microbiology 6 24%
Biochemistry, Genetics and Molecular Biology 5 20%
Medicine and Dentistry 4 16%
Agricultural and Biological Sciences 3 12%
Neuroscience 3 12%
Other 3 12%
Unknown 1 4%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2013.
All research outputs
#13,901,154
of 22,731,677 outputs
Outputs from Journal of Neuroinflammation
#1,498
of 2,615 outputs
Outputs of similar age
#116,157
of 212,391 outputs
Outputs of similar age from Journal of Neuroinflammation
#9
of 18 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,615 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,391 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.