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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Active demethylation in mouse zygotes involves cytosine deamination and base excision repair
|
|---|---|
| Published in |
Epigenetics & Chromatin, November 2013
|
| DOI | 10.1186/1756-8935-6-39 |
| Pubmed ID | |
| Authors |
Fátima Santos, Julian Peat, Heather Burgess, Cristina Rada, Wolf Reik, Wendy Dean |
| Abstract |
DNA methylation in mammals is an epigenetic mark necessary for normal embryogenesis. During development active loss of methylation occurs in the male pronucleus during the first cell cycle after fertilisation. This is accompanied by major chromatin remodelling and generates a marked asymmetry between the paternal and maternal genomes. The mechanism(s) by which this is achieved implicate, among others, base excision repair (BER) components and more recently a major role for TET3 hydroxylase. To investigate these methylation dynamics further we have analysed DNA methylation and hydroxymethylation in fertilised mouse oocytes by indirect immunofluorescence (IF) and evaluated the relative contribution of different candidate factors for active demethylation in knock-out zygotes by three-dimensional imaging and IF semi-quantification. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 60% |
| Spain | 1 | 20% |
| Switzerland | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Switzerland | 1 | <1% |
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 141 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 36% |
| Researcher | 26 | 17% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 14 | 9% |
| Professor > Associate Professor | 6 | 4% |
| Other | 18 | 12% |
| Unknown | 17 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 65 | 43% |
| Biochemistry, Genetics and Molecular Biology | 51 | 34% |
| Chemistry | 5 | 3% |
| Medicine and Dentistry | 3 | 2% |
| Neuroscience | 3 | 2% |
| Other | 3 | 2% |
| Unknown | 20 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2013.
All research outputs
#12,930,646
of 23,314,015 outputs
Outputs from Epigenetics & Chromatin
#338
of 571 outputs
Outputs of similar age
#105,554
of 213,685 outputs
Outputs of similar age from Epigenetics & Chromatin
#7
of 7 outputs
Altmetric has tracked 23,314,015 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 571 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,685 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.