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Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

Overview of attention for article published in Retrovirology, November 2013
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Mentioned by

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2 tweeters

Citations

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4 Dimensions

Readers on

mendeley
24 Mendeley
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1 CiteULike
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Title
Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms
Published in
Retrovirology, November 2013
DOI 10.1186/1742-4690-10-137
Pubmed ID
Authors

Anouk Van Nuffel, Kevin K Ariën, Veronique Stove, Michael Schindler, Eduardo O’Neill, Jan Schmökel, Inge Van de Walle, Evelien Naessens, Hanne Vanderstraeten, Kathleen Van Landeghem, Tom Taghon, Kati Pulkkinen, Kalle Saksela, J Victor Garcia, Oliver T Fackler, Frank Kirchhoff, Bruno Verhasselt

Abstract

A nef gene is present in all primate lentiviral genomes and is important for high viral loads and progression to AIDS in human or experimental macaque hosts of HIV or SIV, respectively. In these hosts, infection of the thymus results in a decreased output of naive T cells that may contribute to the development of immunodeficiency. We have previously shown that HIV-1 subtype B Nef proteins can block human T-cell development. However, the underlying mechanism(s) and the conservation of this Nef function between different groups of HIV and SIV remained to be determined.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Professor 6 25%
Student > Bachelor 4 17%
Student > Ph. D. Student 4 17%
Researcher 4 17%
Student > Doctoral Student 2 8%
Other 4 17%
Readers by discipline Count As %
Immunology and Microbiology 10 42%
Agricultural and Biological Sciences 7 29%
Biochemistry, Genetics and Molecular Biology 4 17%
Arts and Humanities 1 4%
Environmental Science 1 4%
Other 1 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2013.
All research outputs
#9,581,045
of 12,472,057 outputs
Outputs from Retrovirology
#583
of 715 outputs
Outputs of similar age
#112,673
of 176,783 outputs
Outputs of similar age from Retrovirology
#2
of 2 outputs
Altmetric has tracked 12,472,057 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 715 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,783 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.