Title |
Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines
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Published in |
Molecular Cancer, November 2013
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DOI | 10.1186/1476-4598-12-139 |
Pubmed ID | |
Authors |
Wenyu Liu, Gajan Jeganathan, Sohrab Amiri, Katherine M Morgan, Bríd M Ryan, Sharon R Pine |
Abstract |
Stem or progenitor cells from healthy tissues have the capacity to co-segregate their template DNA strands during mitosis. Here, we set out to test whether breast cancer cell lines also possess the ability to asymmetrically segregate their template DNA strands via non-random chromosome co-segregation, and whether this ability correlates with certain properties attributed to breast cancer stem cells (CSCs). We quantified the frequency of asymmetric segregation of template DNA strands in 12 human breast cancer cell lines, and correlated the frequency to molecular subtype, CD44+/CD24-/lo phenotype, and invasion/migration ability. We tested if co-culture with human mesenchymal stem cells, which are known to increase self-renewal, can alter the frequency of asymmetric segregation of template DNA in breast cancer. |
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Mendeley readers
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