Title |
Hypercapnia: is it protective in lung injury?
|
---|---|
Published in |
Medical Gas Research, November 2013
|
DOI | 10.1186/2045-9912-3-23 |
Pubmed ID | |
Authors |
Alexander F Bautista, Ozan Akca |
Abstract |
Hypercapnic acidosis has been regarded as a tolerated side effect of protective lung ventilation strategies. Various in vivo and ex vivo animal studies have shown beneficial effects in acute lung injury setting, but some recent work raised concerns about its anti-inflammatory properties. This mini-review article aims to expand the potential clinical spectrum of hypercapnic acidosis in critically ill patients with lung injury. Despite the proven benefits of hypercapnic acidosis, further safety studies including dose-effect, level-and-onset of anti-inflammatory effect, and safe applicability period need to be performed in various models of lung injury in animals and humans to further elucidate its protective role. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Mexico | 1 | 33% |
Kuwait | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 33% |
Researcher | 6 | 17% |
Other | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Professor > Associate Professor | 2 | 6% |
Other | 6 | 17% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 58% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Veterinary Science and Veterinary Medicine | 2 | 6% |
Nursing and Health Professions | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Other | 3 | 8% |
Unknown | 4 | 11% |