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Familial gastric cancer: detection of a hereditary cause helps to understand its etiology

Overview of attention for article published in Hereditary Cancer in Clinical Practice, December 2012
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Title
Familial gastric cancer: detection of a hereditary cause helps to understand its etiology
Published in
Hereditary Cancer in Clinical Practice, December 2012
DOI 10.1186/1897-4287-10-18
Pubmed ID
Authors

Ingrid P Vogelaar, Rachel S van der Post, Tanya M Bisseling, J Han JM van Krieken, Marjolijn JL Ligtenberg, Nicoline Hoogerbrugge

Abstract

Worldwide, gastric cancer is one of the most common forms of cancer, with a high morbidity and mortality. Several environmental factors predispose to the development of gastric cancer, such as Helicobacter pylori infection, diet and smoking. Familial clustering of gastric cancer is seen in 10% of cases, and approximately 3% of gastric cancer cases arise in the setting of hereditary diffuse gastric cancer (HDGC). In families with HDGC, gastric cancer presents at relatively young age. Germline mutations in the CDH1 gene are the major cause of HDGC and are identified in approximately 25-50% of families which fulfill strict criteria. Prophylactic gastrectomy is the only option to prevent gastric cancer in individuals with a CDH1 mutation. However, in the majority of families with multiple cases of gastric cancer no germline genetic abnormality can be identified and therefore preventive measures are not available, except for general lifestyle advice. Future research should focus on identifying new genetic predisposing factors for all types of familial gastric cancer.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 15%
Researcher 6 12%
Student > Doctoral Student 6 12%
Student > Bachelor 4 8%
Student > Master 4 8%
Other 10 19%
Unknown 14 27%
Readers by discipline Count As %
Medicine and Dentistry 14 27%
Biochemistry, Genetics and Molecular Biology 11 21%
Agricultural and Biological Sciences 6 12%
Unspecified 1 2%
Nursing and Health Professions 1 2%
Other 2 4%
Unknown 17 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2020.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Hereditary Cancer in Clinical Practice
#173
of 260 outputs
Outputs of similar age
#226,511
of 286,181 outputs
Outputs of similar age from Hereditary Cancer in Clinical Practice
#4
of 6 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 260 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,181 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.