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A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling

Overview of attention for article published in Cell Communication and Signaling, November 2013
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Title
A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling
Published in
Cell Communication and Signaling, November 2013
DOI 10.1186/1478-811x-11-89
Pubmed ID
Authors

Anne-Kathrin Gorny, Lilian T Kaufmann, Rajeeb K Swain, Herbert Steinbeisser

Abstract

Activation of the Wnt signalling cascade is primarily based on the interplay between Wnt ligands, their receptors and extracellular modulators. One prominent family of extracellular modulators is represented by the SFRP (secreted Frizzled-related protein) family. These proteins have significant similarity to the extracellular domain of Frizzled receptors, suggesting that they bind Wnt ligands and inhibit signalling. The SFRP-type protein Fz4-v1, a splice variant of the Frizzled-4 receptor found in humans and Xenopus, was shown to augment Wnt/β-catenin signalling, and also interacts with those Wnt ligands that act on β-catenin-independent Wnt pathways.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 5%
Germany 1 5%
Unknown 18 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 30%
Other 4 20%
Student > Master 2 10%
Researcher 2 10%
Student > Bachelor 1 5%
Other 2 10%
Unknown 3 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 45%
Biochemistry, Genetics and Molecular Biology 5 25%
Medicine and Dentistry 2 10%
Neuroscience 1 5%
Design 1 5%
Other 0 0%
Unknown 2 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2013.
All research outputs
#17,703,558
of 22,731,677 outputs
Outputs from Cell Communication and Signaling
#576
of 982 outputs
Outputs of similar age
#219,522
of 302,097 outputs
Outputs of similar age from Cell Communication and Signaling
#7
of 12 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 982 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,097 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.