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ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, November 2013
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Title
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition
Published in
Journal of Experimental & Clinical Cancer Research, November 2013
DOI 10.1186/1756-9966-32-95
Pubmed ID
Authors

Maria Saveria Gilardini Montani, Andrea Prodosmo, Venturina Stagni, Dania Merli, Laura Monteonofrio, Veronica Gatti, Maria Pia Gentileschi, Daniela Barilà, Silvia Soddu

Abstract

Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP-ribose) polymerase (PARP) inhibitors. The ataxia telangiectasia mutated (ATM) kinase is a key DDR protein whose heterozygous germline mutation is a moderate-risk factor for developing breast cancer. In this study, we examined whether ATM inactivation in breast cancer cell lines confers sensitivity to PARP inhibitors.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Canada 1 1%
Unknown 72 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 18%
Student > Bachelor 10 14%
Researcher 10 14%
Student > Ph. D. Student 9 12%
Student > Doctoral Student 6 8%
Other 15 20%
Unknown 11 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 27%
Medicine and Dentistry 16 22%
Agricultural and Biological Sciences 15 20%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Engineering 2 3%
Other 5 7%
Unknown 14 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2013.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#1,635
of 2,378 outputs
Outputs of similar age
#241,390
of 315,599 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#12
of 15 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,378 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,599 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.