Title |
Optical tomographic imaging of near infrared imaging agents quantifies disease severity and immunomodulation of experimental autoimmune encephalomyelitis in vivo
|
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Published in |
Journal of Neuroinflammation, November 2013
|
DOI | 10.1186/1742-2094-10-138 |
Pubmed ID | |
Authors |
Valerie L Eaton, Kristine O Vasquez, Gwendolyn E Goings, Zoe N Hunter, Jeffrey D Peterson, Stephen D Miller |
Abstract |
Experimental autoimmune encephalomyelitis (EAE) is an animal model that captures many of the hallmarks of human multiple sclerosis (MS), including blood-brain barrier (BBB) breakdown, inflammation, demyelination and axonal destruction. The standard clinical score measurement of disease severity and progression assesses functional changes in animal mobility; however, it does not offer information regarding the underlying pathophysiology of the disease in real time. The purpose of this study was to apply a novel optical imaging technique that offers the advantage of rapid imaging of relevant biomarkers in live animals. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 2 | 3% |
Unknown | 63 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 20% |
Student > Ph. D. Student | 10 | 15% |
Student > Master | 8 | 12% |
Other | 6 | 9% |
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Unknown | 17 | 26% |
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