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Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation

Overview of attention for article published in Acta Neuropathologica Communications, November 2013
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Title
Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation
Published in
Acta Neuropathologica Communications, November 2013
DOI 10.1186/2051-5960-1-75
Pubmed ID
Authors

Ayman ElAli, Peter Thériault, Paul Préfontaine, Serge Rivest

Abstract

The Blood-brain barrier (BBB) controls brain supply with oxygen and nutrients, and protects the brain from toxic metabolites, such as beta-amyloid (Aβ) peptides. The neurovascular unit (NVU) couples vascular and neuronal functions by controlling BBB parameters based on brain needs. As such, NVU/BBB dysfunction, associated to irregularities in cerebral blood flow (CBF), has been proposed to contribute in the pathogenesis of Alzheimer's disease (AD), mainly by impairing cerebral Aβ clearance. However, the spatiotemporal contribution of the NVU/BBB in the neurodegenerative cascades remains elusive.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 24%
Student > Master 9 18%
Researcher 8 16%
Other 4 8%
Student > Bachelor 2 4%
Other 7 14%
Unknown 8 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 28%
Medicine and Dentistry 8 16%
Neuroscience 8 16%
Biochemistry, Genetics and Molecular Biology 7 14%
Social Sciences 1 2%
Other 3 6%
Unknown 9 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2013.
All research outputs
#2,898,183
of 3,632,408 outputs
Outputs from Acta Neuropathologica Communications
#114
of 131 outputs
Outputs of similar age
#84,725
of 108,657 outputs
Outputs of similar age from Acta Neuropathologica Communications
#9
of 10 outputs
Altmetric has tracked 3,632,408 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 131 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,657 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.