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Mendeley readers
Attention Score in Context
| Title |
Influence of methylphenidate on brain development – an update of recent animal experiments
|
|---|---|
| Published in |
Behavioral and Brain Functions, January 2006
|
| DOI | 10.1186/1744-9081-2-2 |
| Pubmed ID | |
| Authors |
Thorsten Grund, Konrad Lehmann, Nathalie Bock, Aribert Rothenberger, Gertraud Teuchert-Noodt |
| Abstract |
Methylphenidate (MPH) is the most commonly used drug to treat attention deficit/hyperactivity disorder (ADHD) in children effectively and safely. In spite of its widespread application throughout one of the most plastic and sensitive phases of brain development, very little is known to date about its long-term effects on brain structure and function. Hence, this short review updates the influence of MPH on brain development, since recent human and animal studies suggest that MPH alters the dopaminergic system with long-term effects beyond the termination of treatment.Animal studies imply that the effects of MPH may depend on the neural responder system: Whereas structural and functional parameters are improved by MPH in animals with psychomotor impairments, they remain unaltered or get worse in healthy controls. While recent behavioural studies do not fully support such a differential effect of MPH in ADHD, the animal studies certainly prompt for further investigation of this issue. Furthermore, the abuse of MPH, when (rarely) intravenously applied, may even impair the maturation of dopaminergic fibres in subcortical brain areas. This argues for careful clinical assessment and diagnostics of ADHD symptomatology not only in conjunction with the prescription of MPH. Hence, one should be assured that MPH is only given to children with clear ADHD symptomatology leading to psychosocial impairment. The animal data suggest that under these conditions MPH is supportive for brain development and the related behaviour in children with ADHD. |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Netherlands | 1 | 1% |
| France | 1 | 1% |
| South Africa | 1 | 1% |
| Brazil | 1 | 1% |
| United Kingdom | 1 | 1% |
| Poland | 1 | 1% |
| Unknown | 92 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 21 | 21% |
| Student > Ph. D. Student | 20 | 20% |
| Student > Master | 13 | 13% |
| Researcher | 9 | 9% |
| Other | 6 | 6% |
| Other | 18 | 18% |
| Unknown | 13 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 22 | 22% |
| Medicine and Dentistry | 17 | 17% |
| Neuroscience | 17 | 17% |
| Agricultural and Biological Sciences | 15 | 15% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Other | 8 | 8% |
| Unknown | 17 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2024.
All research outputs
#7,944,688
of 25,382,360 outputs
Outputs from Behavioral and Brain Functions
#129
of 416 outputs
Outputs of similar age
#42,026
of 170,425 outputs
Outputs of similar age from Behavioral and Brain Functions
#2
of 7 outputs
Altmetric has tracked 25,382,360 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 416 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,425 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.