Title |
Detection of hepatitis C virus (HCV) negative strand RNA and NS3 protein in peripheral blood mononuclear cells (PBMC): CD3+, CD14+ and CD19+
|
---|---|
Published in |
Virology Journal, November 2013
|
DOI | 10.1186/1743-422x-10-346 |
Pubmed ID | |
Authors |
Agnieszka Pawełczyk, Natalia Kubisa, Joanna Jabłońska, Iwona Bukowska-Ośko, Kamile Caraballo Cortes, Maria Fic, Tomasz Laskus, Marek Radkowski |
Abstract |
Although hepatitis C virus (HCV) is primarily hepatotropic, markers of HCV replication were detected in peripheral blood mononuclear cells (PBMC) as well as in ex vivo collected tissues and organs. Specific strains of HCV were found to be capable to infect cells of the immune system: T and B cells and monocytes/macrophages as well as cell lines in vitro. The direct invasion of cells of the immune system by the virus may be responsible for extrahepatic consequences of HCV infection: cryoglobulinemia and non-Hodgkin's lymphoma.The aim of the present study was to determine the prevalence of markers of HCV infection: negative strand HCV RNA and non-structural NS3 protein in PBMC subpopulations: CD3+, CD14+ and CD19+. The presence of virus and the proportion of affected cells within a particular PBMC fraction could indicate a principal target cell susceptible for HCV. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 50% |
France | 1 | 13% |
Canada | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Scientists | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 24% |
Researcher | 4 | 16% |
Student > Bachelor | 3 | 12% |
Student > Master | 3 | 12% |
Student > Postgraduate | 2 | 8% |
Other | 4 | 16% |
Unknown | 3 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 24% |
Medicine and Dentistry | 6 | 24% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Immunology and Microbiology | 3 | 12% |
Computer Science | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 20% |