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Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer

Overview of attention for article published in Breast Cancer Research, October 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

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1 X user
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7 patents

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43 Mendeley
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Title
Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer
Published in
Breast Cancer Research, October 2013
DOI 10.1186/bcr3563
Pubmed ID
Authors

Shuiliang Wang, Jingcao Huang, Hui Lyu, Bo Cai, Xiaoping Yang, Fang Li, Jianming Tan, Susan M Edgerton, Ann D Thor, Choon-Kee Lee, Bolin Liu

Abstract

Elevated expression of erbB3 rendered erbB2-overexpressing breast cancer cells resistant to paclitaxel via PI-3 K/Akt-dependent upregulation of Survivin. It is unclear whether an erbB3-targeted therapy may abrogate erbB2-mediated paclitaxel resistance in breast cancer. Here, we study the antitumor activity of an anti-erbB3 antibody MM-121/SAR256212 in combination with paclitaxel against erbB2-overexpressing breast cancer.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 21%
Student > Ph. D. Student 7 16%
Researcher 6 14%
Student > Doctoral Student 3 7%
Student > Bachelor 3 7%
Other 6 14%
Unknown 9 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 23%
Medicine and Dentistry 8 19%
Biochemistry, Genetics and Molecular Biology 6 14%
Chemistry 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Other 2 5%
Unknown 11 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2021.
All research outputs
#5,338,695
of 25,371,288 outputs
Outputs from Breast Cancer Research
#624
of 2,052 outputs
Outputs of similar age
#46,893
of 225,432 outputs
Outputs of similar age from Breast Cancer Research
#15
of 33 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.