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Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer

Overview of attention for article published in Breast Cancer Research, October 2013
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Title
Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer
Published in
Breast Cancer Research, October 2013
DOI 10.1186/bcr3565
Pubmed ID
Authors

Weizhou Zhang, Sergei I Grivennikov

Abstract

Cancer stem cells are likely to play critical roles in metastasis, therapy resistance, and recurrence of hematological and solid malignancies. It is well known that the stem cell niche plays a key role for asymmetric division and homeostasis of normal stem cells, whereas cancer stem cells seem to use these niches. Among many pathways involved in self-renewal of cancer stem cells, nuclear factor-kappa B (NF-κB) signaling has been documented to promote their expansion in a cell-autonomous fashion. A recent study, however, suggests that paracrine NF-κB activation promotes the expansion of cancer stem cells through the activation of Notch in basal-type breast cancer cells.

X Demographics

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 24%
Student > Ph. D. Student 4 19%
Student > Master 3 14%
Student > Doctoral Student 2 10%
Researcher 2 10%
Other 1 5%
Unknown 4 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 29%
Medicine and Dentistry 5 24%
Biochemistry, Genetics and Molecular Biology 4 19%
Physics and Astronomy 1 5%
Engineering 1 5%
Other 0 0%
Unknown 4 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2013.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Breast Cancer Research
#1,882
of 2,052 outputs
Outputs of similar age
#199,346
of 225,509 outputs
Outputs of similar age from Breast Cancer Research
#26
of 33 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,509 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.