Title |
Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer
|
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Published in |
Breast Cancer Research, October 2013
|
DOI | 10.1186/bcr3565 |
Pubmed ID | |
Authors |
Weizhou Zhang, Sergei I Grivennikov |
Abstract |
Cancer stem cells are likely to play critical roles in metastasis, therapy resistance, and recurrence of hematological and solid malignancies. It is well known that the stem cell niche plays a key role for asymmetric division and homeostasis of normal stem cells, whereas cancer stem cells seem to use these niches. Among many pathways involved in self-renewal of cancer stem cells, nuclear factor-kappa B (NF-κB) signaling has been documented to promote their expansion in a cell-autonomous fashion. A recent study, however, suggests that paracrine NF-κB activation promotes the expansion of cancer stem cells through the activation of Notch in basal-type breast cancer cells. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 24% |
Student > Ph. D. Student | 4 | 19% |
Student > Master | 3 | 14% |
Student > Doctoral Student | 2 | 10% |
Researcher | 2 | 10% |
Other | 1 | 5% |
Unknown | 4 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 29% |
Medicine and Dentistry | 5 | 24% |
Biochemistry, Genetics and Molecular Biology | 4 | 19% |
Physics and Astronomy | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 4 | 19% |