Title |
Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani
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Published in |
Cancer Cell International, October 2013
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DOI | 10.1186/1475-2867-13-105 |
Pubmed ID | |
Authors |
Balabhadrapatruni VSK Chakravarthi, Ramanathan Sujay, Gini C Kuriakose, Anjali A Karande, Chelliah Jayabaskaran |
Abstract |
Taxol (generic name paclitaxel), a plant-derived antineoplastic agent, used widely against breast, ovarian and lung cancer, was originally isolated from the bark of the Pacific yew, Taxus brevifolia. The limited supply of the drug has prompted efforts to find alternative sources, such as chemical synthesis, tissue and cell cultures of the Taxus species both of which are expensive and yield low levels. Fermentation processes with microorganisms would be the methods of choice to lower the costs and increase yields. Previously we have reported that F. solani isolated from T. celebica produced taxol and its precursor baccatin III in liquid grown cultures J Biosci 33:259-67, 2008. This study was performed to evaluate the inhibition of proliferation and induction of apoptosis of cancer cell lines by the fungal taxol and fungal baccatin III of F. solani isolated from T. celebica. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 24% |
Student > Master | 7 | 15% |
Researcher | 6 | 13% |
Student > Postgraduate | 5 | 11% |
Student > Bachelor | 4 | 9% |
Other | 7 | 15% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 19 | 41% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Medicine and Dentistry | 3 | 7% |
Environmental Science | 1 | 2% |
Other | 4 | 9% |
Unknown | 9 | 20% |