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Adjuvant therapy with minocycline for schizophrenia (The MINOS Trial): study protocol for a double-blind randomized placebo-controlled trial

Overview of attention for article published in Trials, November 2013
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Title
Adjuvant therapy with minocycline for schizophrenia (The MINOS Trial): study protocol for a double-blind randomized placebo-controlled trial
Published in
Trials, November 2013
DOI 10.1186/1745-6215-14-406
Pubmed ID
Authors

Abebaw Fekadu, Miraf Mesfin, Girmay Medhin, Atalay Alem, Solomon Teferra, Tsehaysina Gebre-Eyesus, Teshale Seboxa, Abraham Assefa, Jemal Hussein, Martha T Lemma, Christina Borba, David C Henderson, Charlotte Hanlon, Teshome Shibre

Abstract

Schizophrenia is understood to be a heterogeneous brain condition with overlapping symptom dimensions. The negative symptom dimension, with its protean cognitive manifestations, responds poorly to treatment, which can be a particular challenge in countries where clozapine therapy is not available. Preliminary data indicate that minocycline may be beneficial adjunct in the treatment of schizophrenia: positive, negative, and cognitive symptoms.In this study we aim to assess the efficacy of adjunctive minocycline to alleviate symptoms of schizophrenia in patients who have failed to respond to a therapeutic trial of antipsychotic medications.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
Unknown 85 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 14%
Researcher 10 12%
Student > Bachelor 9 10%
Student > Doctoral Student 8 9%
Other 7 8%
Other 18 21%
Unknown 22 26%
Readers by discipline Count As %
Medicine and Dentistry 25 29%
Psychology 11 13%
Nursing and Health Professions 6 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Biochemistry, Genetics and Molecular Biology 2 2%
Other 7 8%
Unknown 31 36%