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B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients

Overview of attention for article published in Critical Care, November 2013
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Title
B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients
Published in
Critical Care, November 2013
DOI 10.1186/cc13131
Pubmed ID
Authors

Nicholas J Shubin, Sean F Monaghan, Daithi S Heffernan, Chun-Shiang Chung, Alfred Ayala

Abstract

Sepsis is a deadly inflammatory condition that often leads to an immune suppressed state; however, the events leading to this state remain poorly understood. B and T lymphocyte attenuator (BTLA) is an immune-regulatory receptor shown to effectively inhibit CD4+ T-cell function. Therefore, our objectives were to determine: 1) if lymphocyte BTLA expression was altered in critically ill patients and experimentally induced septic mice, 2) whether augmented CD4+ T-cell BTLA expression was associated with poor septic patient outcomes, and 3) if BTLA expression affected the CD4+ T-cell apoptotic cell loss observed in the lymphoid organs of septic mice.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Germany 1 2%
Brazil 1 2%
Unknown 42 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 18%
Researcher 6 13%
Student > Bachelor 5 11%
Other 4 9%
Student > Ph. D. Student 4 9%
Other 7 16%
Unknown 11 24%
Readers by discipline Count As %
Medicine and Dentistry 12 27%
Immunology and Microbiology 5 11%
Biochemistry, Genetics and Molecular Biology 4 9%
Nursing and Health Professions 3 7%
Agricultural and Biological Sciences 3 7%
Other 5 11%
Unknown 13 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2013.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Critical Care
#5,469
of 6,554 outputs
Outputs of similar age
#205,327
of 320,853 outputs
Outputs of similar age from Critical Care
#73
of 96 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,853 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.