Title |
B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients
|
---|---|
Published in |
Critical Care, November 2013
|
DOI | 10.1186/cc13131 |
Pubmed ID | |
Authors |
Nicholas J Shubin, Sean F Monaghan, Daithi S Heffernan, Chun-Shiang Chung, Alfred Ayala |
Abstract |
Sepsis is a deadly inflammatory condition that often leads to an immune suppressed state; however, the events leading to this state remain poorly understood. B and T lymphocyte attenuator (BTLA) is an immune-regulatory receptor shown to effectively inhibit CD4+ T-cell function. Therefore, our objectives were to determine: 1) if lymphocyte BTLA expression was altered in critically ill patients and experimentally induced septic mice, 2) whether augmented CD4+ T-cell BTLA expression was associated with poor septic patient outcomes, and 3) if BTLA expression affected the CD4+ T-cell apoptotic cell loss observed in the lymphoid organs of septic mice. |
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Mendeley readers
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