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A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rearrangement with apparent insertion at 6q27

Overview of attention for article published in Biomarker Research, November 2013
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Title
A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rearrangement with apparent insertion at 6q27
Published in
Biomarker Research, November 2013
DOI 10.1186/2050-7771-1-31
Pubmed ID
Authors

Carlos A Tirado, David Shabsovich, Matthew DeNicola, Dinesh Rao, Lynn Yang, Rolando Garcia, Nagesh Rao

Abstract

B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in pediatric patients and the leading cause of cancer-related death in children and young adults. Translocations of 9p24 involving JAK2 (9p24) and gain-of-function mutations of JAK2 with subsequent activation of the JAK2 kinase have been described in several hematological malignancies including B-ALL. However, rearrangements involving JAK2 are rare in B-ALL as only few cases have been described in the literature.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 17%
United States 1 17%
Unknown 4 67%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 1 17%
Student > Ph. D. Student 1 17%
Student > Master 1 17%
Researcher 1 17%
Professor > Associate Professor 1 17%
Other 0 0%
Unknown 1 17%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Agricultural and Biological Sciences 1 17%
Biochemistry, Genetics and Molecular Biology 1 17%
Unknown 2 33%