Title |
Does epilepsy in multiplex autism pedigrees define a different subgroup in terms of clinical characteristics and genetic risk?
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Published in |
Molecular Autism, December 2013
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DOI | 10.1186/2040-2392-4-47 |
Pubmed ID | |
Authors |
Claire Amiet, Isabelle Gourfinkel-An, Claudine Laurent, Nicolas Bodeau, Bérengère Génin, Eric Leguern, Sylvie Tordjman, David Cohen |
Abstract |
Autism spectrum disorders (ASD) and epilepsy frequently occur together. Prevalence rates are variable, and have been attributed to age, gender, comorbidity, subtype of pervasive developmental disorder (PDD) and risk factors. Recent studies have suggested disparate clinical and genetic settings depending on simplex or multiplex autism. The aim of this study was to assess: 1) the prevalence of epilepsy in multiplex autism and its association with genetic and non-genetic risk factors of major effect, intellectual disability and gender; and 2) whether autism and epilepsy cosegregate within multiplex autism families. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 23% |
Canada | 1 | 8% |
Chile | 1 | 8% |
Spain | 1 | 8% |
United States | 1 | 8% |
Unknown | 6 | 46% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 69% |
Practitioners (doctors, other healthcare professionals) | 3 | 23% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 1% |
Unknown | 89 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 17% |
Student > Master | 15 | 17% |
Student > Ph. D. Student | 12 | 13% |
Student > Bachelor | 7 | 8% |
Student > Doctoral Student | 6 | 7% |
Other | 16 | 18% |
Unknown | 19 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 20 | 22% |
Medicine and Dentistry | 12 | 13% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Neuroscience | 6 | 7% |
Computer Science | 5 | 6% |
Other | 16 | 18% |
Unknown | 25 | 28% |