Title |
Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine
|
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Published in |
Genome Medicine, November 2013
|
DOI | 10.1186/gm509 |
Pubmed ID | |
Authors |
Daniel Bottomly, Peter A Ryabinin, Jeffrey W Tyner, Bill H Chang, Marc M Loriaux, Brian J Druker, Shannon K McWeeney, Beth Wilmot |
Abstract |
Patient-specific aberrant expression patterns in conjunction with functional screening assays can guide elucidation of the cancer genome architecture and identification of therapeutic targets. Since most statistical methods for expression analysis are focused on differences between experimental groups, the performance of approaches for patient-specific expression analyses are currently less well characterized. A comparison of methods for the identification of genes that are dysregulated relative to a single sample in a given set of experimental samples, to our knowledge, has not been performed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 67% |
Germany | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 23% |
Student > Ph. D. Student | 7 | 20% |
Other | 4 | 11% |
Student > Master | 4 | 11% |
Student > Bachelor | 2 | 6% |
Other | 5 | 14% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 40% |
Biochemistry, Genetics and Molecular Biology | 6 | 17% |
Mathematics | 3 | 9% |
Medicine and Dentistry | 2 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Other | 4 | 11% |
Unknown | 5 | 14% |