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The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial

Overview of attention for article published in Trials, April 2017
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Title
The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial
Published in
Trials, April 2017
DOI 10.1186/s13063-017-1937-0
Pubmed ID
Authors

Tor A. Strand, Manjeswori Ulak, Ram K. Chandyo, Ingrid Kvestad, Mari Hysing, Merina Shrestha, Sudha Basnet, Suman Ranjitkar, Laxman Shrestha, Prakash S. Shrestha

Abstract

Vitamin B12 deficiency is one of the most common micronutrient deficiencies and is associated with poor cognitive development and growth. Vitamin B12 is crucial for normal cell division and differentiation, and it is necessary for the development and myelination of the central nervous system. The aim of the present study is to measure the effect of daily supplementation of vitamin B12 on the neurodevelopment and growth of young children in Nepal. We are conducting an individually randomized, double-blind, placebo-controlled trial with 600 marginally stunted children 6-11 months old (length for age less than -1 z-score). Children are randomized to receive a lipid-based paste containing vitamin B12 or placebo daily for 12 months. The main outcomes are changes in growth (z-scores) and in neurodevelopment measured by the Bayley Scales of Infant and Toddler Development, Third Edition, from baseline until the end of the study. If vitamin B12 supplementation benefits early child development and growth, this will have consequences for dietary recommendations for malnourished children worldwide. ClinicalTrials.gov Identifier: NCT02272842 . Registered on 21 October 2014. Universal Trial Number: U1111-1161-5187. Registered on 8 September 2014.

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Mendeley readers

The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 128 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 15%
Student > Master 16 13%
Researcher 14 11%
Student > Ph. D. Student 11 9%
Student > Doctoral Student 4 3%
Other 14 11%
Unknown 50 39%
Readers by discipline Count As %
Nursing and Health Professions 28 22%
Medicine and Dentistry 20 16%
Biochemistry, Genetics and Molecular Biology 7 5%
Social Sciences 6 5%
Agricultural and Biological Sciences 5 4%
Other 13 10%
Unknown 49 38%