Title |
Absence of the dermatan sulfate chain of decorin does not affect mouse development
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Published in |
Journal of Negative Results in BioMedicine, April 2017
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DOI | 10.1186/s12952-017-0074-3 |
Pubmed ID | |
Authors |
Pierre Moffatt, Yeqing Geng, Lisa Lamplugh, Antonio Nanci, Peter J. Roughley |
Abstract |
In vitro studies suggest that the multiple functions of decorin are related to both its core protein and its dermatan sulfate chain. To determine the contribution of the dermatan sulfate chain to the functional properties of decorin in vivo, a mutant mouse whose decorin lacked a dermatan sulfate chain was generated. Homozygous mice expressing only the decorin core protein developed and grew in a similar manner to wild type mice. In both embryonic and postnatal mice, all connective tissues studied, including cartilage, skin and cornea, appeared to be normal upon histological examination, and their collagen fibrils were of normal diameter and organization. In addition, abdominal skin wounds healed in an identical manner in the mutant and wild type mice. The absence of a dermatan sulfate chain on decorin does not appear to overtly influence its functional properties in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Argentina | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 3 | 23% |
Student > Ph. D. Student | 3 | 23% |
Other | 2 | 15% |
Student > Doctoral Student | 1 | 8% |
Lecturer > Senior Lecturer | 1 | 8% |
Other | 3 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 46% |
Biochemistry, Genetics and Molecular Biology | 3 | 23% |
Agricultural and Biological Sciences | 2 | 15% |
Engineering | 1 | 8% |
Unknown | 1 | 8% |