Title |
Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus
|
---|---|
Published in |
BMC Immunology, August 2013
|
DOI | 10.1186/1471-2172-14-37 |
Pubmed ID | |
Authors |
Yingxia Liu, Shaoyuan Li, Guoliang Zhang, Guang Nie, Zhizhong Meng, Dongting Mao, Chang Chen, Xinchun Chen, Boping Zhou, Gucheng Zeng |
Abstract |
Host genetic variations may contribute to disease susceptibility of influenza. IL-1A and IL-1B are important inflammatory cytokines that mediate the inflammation and initiate the immune response against virus infection. In this study, we investigated the relationship between single-nucleotide polymorphisms (SNPs) of Interleukin-1A (IL-1A) and Interleukin-1B (IL-1B) and the susceptibility to 2009 pandemic A/H1N1 influenza (A(H1N1)pdm09). 167 patients whom were confirmed with A(H1N1)pdm09 and 192 healthy controls were included in this study. Four SNPs (rs1304037, rs16347, rs17561, rs2071373) in IL1A gene and three SNPs (rs1143623, rs3917345, rs1143627) in IL1B gene were genotyped by using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry platform, and the associations of the genetic variants of IL-1 with susceptibility to A(H1N1)pdm09 were then assessed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 25% |
Researcher | 14 | 24% |
Student > Master | 8 | 14% |
Student > Bachelor | 6 | 10% |
Professor > Associate Professor | 3 | 5% |
Other | 5 | 8% |
Unknown | 8 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 20% |
Medicine and Dentistry | 10 | 17% |
Agricultural and Biological Sciences | 10 | 17% |
Immunology and Microbiology | 8 | 14% |
Veterinary Science and Veterinary Medicine | 3 | 5% |
Other | 7 | 12% |
Unknown | 9 | 15% |