Title |
Immunogenicity and efficacy of a chimpanzee adenovirus-vectored Rift Valley Fever vaccine in mice
|
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Published in |
Virology Journal, December 2013
|
DOI | 10.1186/1743-422x-10-349 |
Pubmed ID | |
Authors |
George M Warimwe, Gema Lorenzo, Elena Lopez-Gil, Arturo Reyes-Sandoval, Matthew G Cottingham, Alexandra J Spencer, Katharine A Collins, Matthew DJ Dicks, Anita Milicic, Amar Lall, Julie Furze, Alison V Turner, Adrian VS Hill, Alejandro Brun, Sarah C Gilbert |
Abstract |
Rift Valley Fever (RVF) is a viral zoonosis that historically affects livestock production and human health in sub-Saharan Africa, though epizootics have also occurred in the Arabian Peninsula. Whilst an effective live-attenuated vaccine is available for livestock, there is currently no licensed human RVF vaccine. Replication-deficient chimpanzee adenovirus (ChAd) vectors are an ideal platform for development of a human RVF vaccine, given the low prevalence of neutralizing antibodies against them in the human population, and their excellent safety and immunogenicity profile in human clinical trials of vaccines against a wide range of pathogens. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 20% |
United States | 2 | 20% |
Spain | 2 | 20% |
Costa Rica | 1 | 10% |
Unknown | 3 | 30% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 90% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Kenya | 2 | 3% |
Unknown | 76 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 21 | 27% |
Student > Ph. D. Student | 14 | 18% |
Student > Master | 10 | 13% |
Student > Bachelor | 8 | 10% |
Student > Doctoral Student | 3 | 4% |
Other | 7 | 9% |
Unknown | 15 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 27% |
Biochemistry, Genetics and Molecular Biology | 12 | 15% |
Immunology and Microbiology | 10 | 13% |
Medicine and Dentistry | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 8 | 10% |
Unknown | 18 | 23% |