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Allosteric induction of the CD4-bound conformation of HIV-1 Gp120

Overview of attention for article published in Retrovirology, December 2013
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Title
Allosteric induction of the CD4-bound conformation of HIV-1 Gp120
Published in
Retrovirology, December 2013
DOI 10.1186/1742-4690-10-147
Pubmed ID
Authors

Anna Roitburd-Berman, Gal Dela, Gilad Kaplan, George K Lewis, Jonathan M Gershoni

Abstract

HIV-1 infection of target cells is mediated via the binding of the viral envelope protein, gp120, to the cell surface receptor CD4. This interaction leads to conformational rearrangements in gp120 forming or revealing CD4 induced (CD4i) epitopes which are critical for the subsequent recognition of the co-receptor required for viral entry. The CD4-bound state of gp120 has been considered a potential immunogen for HIV-1 vaccine development. Here we report on an alternative means to induce gp120 into the CD4i conformation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 29%
Student > Ph. D. Student 4 24%
Student > Bachelor 2 12%
Student > Master 2 12%
Student > Doctoral Student 1 6%
Other 0 0%
Unknown 3 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 29%
Medicine and Dentistry 3 18%
Agricultural and Biological Sciences 2 12%
Nursing and Health Professions 1 6%
Immunology and Microbiology 1 6%
Other 1 6%
Unknown 4 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2016.
All research outputs
#14,767,396
of 22,733,113 outputs
Outputs from Retrovirology
#734
of 1,105 outputs
Outputs of similar age
#185,564
of 306,767 outputs
Outputs of similar age from Retrovirology
#36
of 63 outputs
Altmetric has tracked 22,733,113 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,105 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,767 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.