Title |
Estrogen aggravates inflammation in Pseudomonas aeruginosa pneumonia in cystic fibrosis mice
|
---|---|
Published in |
Respiratory Research, November 2010
|
DOI | 10.1186/1465-9921-11-166 |
Pubmed ID | |
Authors |
Yufa Wang, Elvis Cela, Stéphane Gagnon, Neil B Sweezey |
Abstract |
Among patients with cystic fibrosis (CF), females have worse pulmonary function and survival than males, primarily due to chronic lung inflammation and infection with Pseudomonas aeruginosa (P. aeruginosa). A role for gender hormones in the causation of the CF "gender gap" has been proposed. The female gender hormone 17β-estradiol (E2) plays a complex immunomodulatory role in humans and in animal models of disease, suppressing inflammation in some situations while enhancing it in others. Helper T-cells were long thought to belong exclusively to either T helper type 1 (Th1) or type 2 (Th2) lineages. However, a distinct lineage named Th17 is now recognized that is induced by interleukin (IL)-23 to produce IL-17 and other pro-inflammatory Th17 effector molecules. Recent evidence suggests a central role for the IL-23/IL-17 pathway in the pathogenesis of CF lung inflammation. We used a mouse model to test the hypothesis that E2 aggravates the CF lung inflammation that occurs in response to airway infection with P. aeruginosa by a Th17-mediated mechanism. |
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Canada | 1 | 100% |
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Mendeley readers
Geographical breakdown
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Ireland | 1 | 1% |
Canada | 1 | 1% |
Unknown | 69 | 96% |
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Student > Ph. D. Student | 15 | 21% |
Researcher | 10 | 14% |
Student > Master | 8 | 11% |
Student > Doctoral Student | 5 | 7% |
Student > Bachelor | 4 | 6% |
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Unknown | 16 | 22% |
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Veterinary Science and Veterinary Medicine | 2 | 3% |
Other | 4 | 6% |
Unknown | 20 | 28% |