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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effects of escitalopram and paroxetine on mTORC1 signaling in the rat hippocampus under chronic restraint stress
|
|---|---|
| Published in |
BMC Neuroscience, April 2017
|
| DOI | 10.1186/s12868-017-0357-0 |
| Pubmed ID | |
| Authors |
Mi Kyoung Seo, Cheol Min Choi, Roger S. McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B. Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park, Jung Goo Lee |
| Abstract |
Recent studies have suggested that the activation of mammalian target of rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, the present study evaluated whether antidepressant drugs would exert differential effects on mTOR signaling in the rat hippocampus under conditions of chronic restraint stress. Male Sprague-Dawley rats were subjected to restraint stress for 6 h/days for 21 days with either escitalopram (10 mg/kg) or paroxetine (10 mg/kg) administered after the chronic stress procedure. Western blot analyses were used to assess changes in the levels of phospho-Ser(2448)-mTOR, phospho-Thr(37/46)-4E-BP-1, phospho-Thr(389)-p70S6 K, phospho-Ser(422)-eIF4B, phospho-Ser(240/244)-S6, phospho-Ser(473)-Akt, and phospho-Thr(202)/Tyr(204)-ERK in the hippocampus. Chronic restraint stress significantly decreased the levels of phospho-mTOR complex 1 (mTORC1), phospho-4E-BP-1, phospho-p70S6 K, phospho-eIF4B, phospho-S6, phospho-Akt, and phospho-ERK (p < 0.05); the administration of escitalopram and paroxetine increased the levels of all these proteins (p < 0.05 or 0.01). Additionally, chronic restraint stress reduced phospho-mTORC1 signaling activities in general, while escitalopram and paroxetine prevented these changes in phospho-mTORC1 signaling activities. These findings provide further data that contribute to understanding the possible relationships among mTOR activity, stress, and antidepressant drugs. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Italy | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 17% |
| Student > Master | 6 | 14% |
| Researcher | 5 | 12% |
| Student > Bachelor | 4 | 10% |
| Other | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 16 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 12% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Medicine and Dentistry | 3 | 7% |
| Agricultural and Biological Sciences | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 21 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2017.
All research outputs
#17,887,790
of 22,965,074 outputs
Outputs from BMC Neuroscience
#819
of 1,250 outputs
Outputs of similar age
#220,631
of 309,791 outputs
Outputs of similar age from BMC Neuroscience
#13
of 17 outputs
Altmetric has tracked 22,965,074 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,250 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,791 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.